New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis
I Striz, K Golebski, Z Strizova, S Loukides… - Clinical …, 2023 - portlandpress.com
Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP) are
chronic respiratory diseases. These two disorders often co-exist based on common …
chronic respiratory diseases. These two disorders often co-exist based on common …
Treatment of allergy: Overview of synthetic anti-allergy small molecules in medicinal chemistry
S Zhang, Y Liu, A Javeed, C Jian, J Sun, S Wu… - European Journal of …, 2023 - Elsevier
The prevalence of allergic diseases has been continuously increasing over the past few
decades, affecting approximately 20–30% of the global population. Allergic reactions to …
decades, affecting approximately 20–30% of the global population. Allergic reactions to …
Targeted GATA3 knockdown in activated T cells via pulmonary siRNA delivery as novel therapy for allergic asthma
R Kandil, D Baldassi, S Böhlen, JT Müller… - Journal of Controlled …, 2023 - Elsevier
GATA3 gene silencing in activated T cells displays a promising option to early-on undermine
pathological pathways in the disease formation of allergic asthma. The central transcription …
pathological pathways in the disease formation of allergic asthma. The central transcription …
Dietary polyphenols ameliorate inflammatory bowel diseases: advances and future perspectives to maximize their nutraceutical applications
W Zhong, J Gong, Q Su, MA Farag… - Phytochemistry …, 2023 - Springer
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease, and in the
face of limitations such as drug resistance and side effects of traditional drugs, there is …
face of limitations such as drug resistance and side effects of traditional drugs, there is …
CC group of chemokines and associated gene expression of transcription factors: deciphering immuno-pathogenetic aspect of oral submucous fibrosis
Background Oral submucous fibrosis (OSMF) is a chronic disease with significantly
increasing malignant transformation rate. To date the pathogenesis of OSMF has been …
increasing malignant transformation rate. To date the pathogenesis of OSMF has been …
An antioxidant ameliorates allergic airway inflammation by inhibiting Hdac 1 via Hif-1α/Vegf axis suppression in mice
R Islam, D Dash, R Singh - Scientific Reports, 2023 - nature.com
Histone deacetylase inhibitors (HDACi) are novel class of drugs as they are involved in post
translational modification of several proteins involved in signaling pathways related to …
translational modification of several proteins involved in signaling pathways related to …
[HTML][HTML] Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1
WX Zhu, Y Xi, F Li, WE Jiao, ZJ Li, SM Chen, YG Kong… - Heliyon, 2023 - cell.com
Cigarette smoke exposure is an important factor in chronic inflammation in patients with
allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related …
allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related …
The GLCCI1 rs37973 variant and the efficacy of inhaled corticosteroids in the treatment of asthma: A meta‐analysis
WL Feng, W Pu, J Li, Y Yuan, MZ Yan… - The Clinical …, 2023 - Wiley Online Library
Objective This study investigated the relationship between the glucocorticoid‐induced
transcript 1 (GLCCI1) gene variant and the degree of improvement in lung function with …
transcript 1 (GLCCI1) gene variant and the degree of improvement in lung function with …
Immune cell ratio and coagulation markers in assessing prognosis of asthma: a cross-sectional study from Saudi Arabia
FM Aldakheel, ZA Alruwaili, SA Alduraywish… - Frontiers in …, 2023 - frontiersin.org
Asthma affects a significant number of individuals in Saudi Arabia, with increasing
prevalence worldwide, leading to a considerable impact on their quality of life and frequent …
prevalence worldwide, leading to a considerable impact on their quality of life and frequent …
[HTML][HTML] Molecular mechanisms of steroid-resistant asthma
Steroid-resistant asthma (SRA) is clinically significant, approximately 10–15% of individuals
with asthma do not exhibit a positive response to standard treatments. While this subset …
with asthma do not exhibit a positive response to standard treatments. While this subset …