Advances in a scientific discipline are often measured by small, incremental steps. In this
review, we report on two intertwined disciplines in the protein structure prediction field …

Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

Understanding how proteins structurally interact is crucial to modern biology, with
applications in drug discovery and protein design. Recent machine learning methods have …

Serratiopeptidase is the multifunctionality metalloendopeptidase extensively employed in
biopharmaceutical and industrial biotechnology. Despite its poor pH tolerance …

Background The molecular dynamics is an approach to obtain kinetic and thermodynamic
characteristics of biomolecular structures. The molecular dynamics simulation softwares are …

An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …

Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs),
which are proteins that cause post-synaptic blockade and paralysis in snakebite …

Extensive studies demonstrate the importance of the STING1 (also known as STING) protein
as a signaling hub that coordinates immune and autophagic responses to ectopic DNA in …

The coronavirus disease 2019 virus outbreak continues worldwide, with many variants
emerging, some of which are considered variants of concern (VOCs). The WHO designated …

Peptide toxins that adopt the ShK fold can inhibit the voltage-gated potassium channel KV1.
3 with IC50 values in the pM range and are therefore potential leads for drugs targeting …