Low‐molecular weight inhibitors of the alternative complement pathway
A Schubart, S Flohr, T Junt, J Eder - Immunological Reviews, 2023 - Wiley Online Library
Dysregulation of the alternative complement pathway predisposes individuals to a number
of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to …
of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to …
Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)‐driven Complement‐mediated Diseases
BG Gibson, TE Cox, KJ Marchbank - Immunological Reviews, 2023 - Wiley Online Library
This review aimed to capture the key findings that animal models have provided around the
role of the alternative pathway and amplification loop (AP/AL) in disease. Animal models …
role of the alternative pathway and amplification loop (AP/AL) in disease. Animal models …
Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors
JY Chen, L Zhang, M Yang, ED Hughes… - Journal of Innate …, 2023 - karger.com
Introduction: C3 is central for all complement activation pathways, thus making it an
attractive therapeutic target. Many C3-targeted agents are under extensive development …
attractive therapeutic target. Many C3-targeted agents are under extensive development …
[引用][C] Development of a C3 Humanized Rat as a New Model for Evaluating Novel C3 Inhibitors
JYCLZ Maojing, YED Hughesb, ZT Freemanb… - 2023 - europepmc.org
Introduction: C3 is central for all complement activation pathways, thus making it an
attractive therapeutic target. Many C3-targeted agents are under extensive development …
attractive therapeutic target. Many C3-targeted agents are under extensive development …