[HTML][HTML] Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup

A Zarbock, MK Nadim, P Pickkers, H Gomez… - Nature Reviews …, 2023 - nature.com
Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is
strongly associated with adverse outcomes, including an increased risk of chronic kidney …

[HTML][HTML] How I personalize fluid therapy in septic shock?

X Monnet, C Lai, JL Teboul - Critical Care, 2023 - Springer
During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue
oxygenation, but it poses two problems: it has inconsistent and transient efficacy, and it has …

Lactate activates the mitochondrial electron transport chain independently of its metabolism

X Cai, CP Ng, O Jones, TS Fung, KW Ryu, D Li… - Molecular cell, 2023 - cell.com
Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial

MG Collins, MA Fahim, EM Pascoe, CM Hawley… - The Lancet, 2023 - thelancet.com
Background Delayed graft function (DGF) is a major adverse complication of deceased
donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a …

[HTML][HTML] Clinical practice guidelines for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons and the Society of …

JL Irani, TL Hedrick, TE Miller, L Lee… - Diseases of the Colon …, 2023 - journals.lww.com
This publication was approved by both the ASCRS and SAGES executive council and then
peer-reviewed by the Diseases of the Colon & Rectum and Surgical Endoscopy And Other …

[HTML][HTML] The European guideline on management of major bleeding and coagulopathy following trauma

R Rossaint, A Afshari, B Bouillon, V Cerny… - Critical Care, 2023 - Springer
Background Severe trauma represents a major global public health burden and the
management of post-traumatic bleeding continues to challenge healthcare systems around …

Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection: the ACORN randomized clinical trial

ET Qian, JD Casey, A Wright, L Wang, MS Shotwell… - JAMA, 2023 - jamanetwork.com
Importance Cefepime and piperacillin-tazobactam are commonly administered to
hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has …

[HTML][HTML] Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2 …

MJ Scott, G Aggarwal, RJ Aitken, ID Anderson… - World journal of …, 2023 - Springer
Abstract Background This is Part 2 of the first consensus guidelines for optimal care of
patients undergoing emergency laparotomy (EL) using an Enhanced Recovery After …

Endothelial and glycocalyx biomarkers in children with sepsis after one bolus of unbalanced or balanced crystalloids

J Fernández-Sarmiento… - Pediatric Critical Care …, 2023 - journals.lww.com
OBJECTIVES: To assess the disruption of endothelial glycocalyx integrity in children with
sepsis receiving fluid resuscitation with either balanced or unbalanced crystalloids. The …

Machine-learning-derived sepsis bundle of care

A Kalimouttou, I Lerner, C Cheurfa, AS Jannot… - Intensive Care …, 2023 - Springer
Abstract Purpose Compliance to the Surviving Sepsis Campaign (SSC) guidelines is limited.
This is known to be associated with increased mortality. The aim of this retrospective cohort …