Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease

J Żukowska, SJ Moss, V Subramanian… - The FEBS …, 2023 - Wiley Online Library
The accumulation of the small 42‐residue long peptide amyloid‐β (Aβ) has been proposed
as a major trigger for the development of Alzheimer's disease (AD). Within the brain, the …

Therapeutic potential of extracellular vesicles in neurodegenerative disorders

S Roudi, JA Rädler, S El Andaloussi - Handbook of Clinical Neurology, 2023 - Elsevier
Neurodegenerative disorders are characterized by complex multifactorial pathogeneses,
thus posing a challenge for standard therapeutic approaches that tend to focus only on one …

[HTML][HTML] LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease

Y Yang, M García-Cruzado, H Zeng… - Brain, Behavior, and …, 2023 - Elsevier
Microglia have an innate immunity memory (IIM) with divergent functions in different animal
models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is …

Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition

HA Rowland, SR Moxon, NJ Corbett… - Neuronal …, 2023 - portlandpress.com
Alzheimer's disease (AD) is characterised by the aggregation and deposition of amyloid-β
(Aβ) peptides in the human brain. In age-related late-onset AD, deficient degradation and …

Correlation between insulin-degrading enzyme versus total tau and selected cytokines in patients with Alzheimer´ s disease compared to non-demented controls.

H Kullenberg, T Nyström, M Kumlin… - Neuro Endocrinology …, 2023 - diva-portal.org
OBJECTIVE: It has been increasingly recognized that the pathological progress of
Alzheimers disease (AD) is connected to metabolic function and inflammation. Insulin …

Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein …

AD Buzoianu, A Sharma, DF Muresanu, L Feng… - … in Nanomedicine in …, 2023 - Springer
Parkinson's disease (PD) in military personnel engaged in combat operations is likely to
develop in their later lives. In order to enhance the quality of lives of PD patients, exploration …

[PDF][PDF] Étude de l'interaction de l'insuline avec la barrière hémato-encéphalique dans la maladie d'Alzheimer

M Leclerc - 2023 - corpus.ulaval.ca
Résumé Les maladies neurodégénératives se caractérisent par des accumulations
anormales de protéines spécifiques dans le cerveau qui sont associées à la perte de …

Effects of Aerobic Exercise on Rage and LRP1 in STZ and HFD Models of Diabetes: Relationship With Cognitive Function and Aβ Clearance

CJ Frank - 2023 - search.proquest.com
The number of individuals with diabetes worldwide has quadrupled since 1980, making
diabetes the 4th most common cause of death from non-communicable disease. Since …

Insulin-Degrading Enzyme: A link between insulin resistance and Alzheimer's disease

H Kullenberg - 2023 - diva-portal.org
Background: Prior research has demonstrated an elevated risk of Alzheimer's disease (AD)
among individuals diagnosed with type 2 diabetes mellitus (T2DM). Insulin resistance is a …

SAMANTHA ROUDI", JULIA ANNA RÄDLER", AND SAMIR EL ANDALOUSSI

AJ Espay - … Medicine in Neurodegenerative Disorders: Part II, 2023 - books.google.com
Neurodegenerative disorders are characterized by complex multifactorial pathogeneses,
thus posing a challenge for standard therapeutic approaches that tend to focus only on one …