Abstract mRNA delivery has shown high application value in the treatment of various
diseases, but its effective delivery is still a major challenge at present. Herein, we propose a …

Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB
efficacy but resistance to ICB remains a clinical challenge and is attributed to highly plastic …

Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among
patients with colorectal cancer (CRC). Although immunotherapy has demonstrated …

Simple Summary The poor prognosis outcome of patients with KRAS mutations (KRAS mut)
was correlated with an immunosuppressive tumor microenvironment (TME). At the gene …

Glioblastoma multiforme (GBM) is the most aggressive form of adult brain tumor which is
highly resistant to conventional treatment and therapy. Glioma cells are highly motile …

Neutrophils (PMNs) execute important effector functions protecting the host against invading
pathogens, however their activity in tissue can exacerbate inflammation and inflammation …

Enhancer of zeste homolog 2 (EZH2), a core component of polycomb repressive component
2 is overexpressed in a variety of cancers and recognized as a therapeutic target molecule …

Osteoprotegerin (OPG) is a secreted cytokine that functions as a decoy receptor for receptor
activator of nuclear factor kappa-B (RANK) ligand (RANKL). Anti-RANKL treatment for bone …

Colorectal cancer (CRC) is a significant problem affecting patients all over the world. Since it
is the fourth most common cause of cancer-related deaths, many scientists aim to expand …

Therapy on lipid metabolism is emerging as a groundbreaking cancer treatment, offering the
unprecedented opportunity to effectively treat and in several cases. Tumorigenesis is …