A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases

KC Barnett, S Li, K Liang, JPY Ting - Cell, 2023 - cell.com
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

[HTML][HTML] Innate immune evasion strategies of SARS-CoV-2

JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …

[HTML][HTML] COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Autoimmune and autoinflammatory connective tissue disorders following COVID-19

SH Lim, HJ Ju, JH Han, JH Lee, WS Lee… - JAMA network …, 2023 - jamanetwork.com
Importance Multiple cases of autoimmune and autoinflammatory diseases after COVID-19
have been reported. However, their incidences and risks have rarely been quantified …

Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review

L Ghosn, R Assi, T Evrenoglou… - Cochrane database …, 2023 - cochranelibrary.com
Background It has been reported that people with COVID‐19 and pre‐existing
autoantibodies against type I interferons are likely to develop an inflammatory cytokine storm …

[HTML][HTML] Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …

[HTML][HTML] A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

[HTML][HTML] Impact of COVID-19 on cardiovascular disease

I Vosko, A Zirlik, H Bugger - Viruses, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a viral infection with the novel severe acute
respiratory distress syndrome corona virus 2 (SARS-CoV-2). Until now, more than 670 …

[HTML][HTML] An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

KC Barnett, Y Xie, T Asakura, D Song, K Liang… - Cell Host & Microbe, 2023 - cell.com
Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19.
Investigating the underlying mechanisms, we find that while primary human airway epithelia …

Neutrophil activation and neutrophil extracellular traps (NETs) in COVID‐19 ARDS and immunothrombosis

MC Cesta, M Zippoli, C Marsiglia… - European Journal of …, 2023 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is an acute inflammatory condition with a
dramatic increase in incidence since the beginning of the coronavirus disease 19 (COVID …