Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

Antibiotic resistance poses a global health threat, but the within-host drivers of resistance
remain poorly understood. Pathogen populations are often assumed to be clonal within …

Antibiotic resistance in Pseudomonas aeruginosa remains one of the most challenging
phenomena of everyday medical science. The universal spread of high-risk clones of …

Antibiotics that have multiple cellular targets theoretically reduce the frequency of resistance
evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are …

Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in
people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF …

Objective Acute exacerbations of biofilm-associated Pseudomonas aeruginosa infections in
cystic fibrosis (CF) have limited treatment options. Ceftolozane/tazobactam (alone and with a …

Collateral sensitivity (CS) is an evolutionary trade-off by which acquisition of resistance to an
antibiotic leads to increased susceptibility to another. This Achilles' heel of antibiotic …

The Pseudomonas aeruginosa genome can change to adapt to different ecological niches.
We compared four genomes from a Mexican hospital and 59 genomes from GenBank from …