Nuclear pore complexes (NPCs) play a critical role in maintaining the equilibrium between
the nucleus and cytoplasm, enabling bidirectional transport across the nuclear envelope …

The cytoplasmic aggregation of TAR DNA binding protein-43 (TDP-43), also known as TDP-
43 pathology, is the pathological hallmark of amyotrophic lateral sclerosis (ALS). However …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset
neurodegenerative diseases that are part of a common disease spectrum due to clinical …

G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are
the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal …

The aberrant expansion of GGGGCC hexanucleotide repeats within the first intron of the
C9orf72 gene represent the predominant genetic etiology underlying amyotrophic lateral …

Mitochondrial dysfunction such as excess production of reactive oxygen species (ROS) and
defective mitochondrial dynamics are common features of C9orf72 Amyotrophic Lateral …

The degeneration of axons and their terminals occurs following traumatic, toxic, or
genetically-induced insults. Common molecular mechanisms unite these disparate triggers …

Neuropathological features of frontotemporal dementia and amyotrophic lateral sclerosis
(ALS) due to C9orf72 GGGGCC hexanucleotide repeat expansion include early dipeptide …

The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one …

Neurodegenerative diseases are characterized by the abnormal accumulation of disease-
driving proteins. Emerging evidence suggests that nucleocytoplasmic transport (NCT) …