The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

The introduction of β-adrenergic receptor blockers,“β-blockers”, as a treatment for heart
failure decades ago was a major advance in cardiovascular medicine 1–4. Moreover, it has …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …

Introduction Strong scientific evidence and large experience support the use of β2-agonists
for the symptomatic alleviation of COPD. Therefore, there is considerable effort in …

Modular proteins are regulatory proteins that carry out more than one function. These
proteins upregulate or downregulate a biochemical cascade to establish homeostasis in …

Although β1-adrenoceptor (β1-AR) signal transduction, which maintains cardiac function, is
downregulated in failing hearts, the mechanisms for such a defect in heart failure are not …

Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug
discovery. Despite decades of research, a molecular-level understanding of the general …

Background: Mucociliary clearance is a pivotal physiological mechanism that protects the
lung by ridding the lower airways of pollution and colonization by pathogens, thereby …

The lethality of heart failure (HF), particularly in the context of post-acute sequelae SARS-
CoV-2 infection (PASC)-related myocarditis, necessitates the discovery of the cellular …