Owing to the increase in multidrug‐resistant bacterial isolates in hospitals globally and the
lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have …

Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …

Insects can assemble defensive microbiomes on their body surfaces to defend against
fungal parasitic infections. The strategies employed by fungal pathogens to combat host …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Highlights•Insect cuticles are inhabited by diverse microorganisms.•Insect ectomicrobiomes
can mediate colonization resistance against fungal parasites.•Fungal pathogens can …

Antimicrobial peptides (AMPs) are natural biopolymers in the host defense system. AMPs
display multiple functions against bacterial, fungal, and viral infection, as well as anticancer …

Pichia pastoris is the widely used expression system for producing recombinant secretory
proteins. It is known that Kex2 protease plays a vital role in the process of protein secretion …

Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …

Although antimicrobial peptides (AMPs) have highly desirable intrinsic characteristics in
their commercial product development as new antimicrobials, the limitations of AMPs from …