Homotypic chromatin interactions and loop extrusion are thought to be the two main drivers
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …

The tumour suppressor p53, a stress‐responsive transcription factor, plays a central role in
cellular senescence. The role of p53 in senescence‐associated stable proliferative arrest …

Cellular senescence, a persistent form of cell cycle arrest, has been linked to the formation
of heterochromatic foci, accompanied by additional concentric epigenetic layers. However …

Cellular senescence and senescence-associated secretory phenotype (SASP) in stromal
cells within the tumor microenvironment promote cancer progression. Although cellular …

The human brain is a complex organ comprised of distinct cell types, and the contribution of
the 3D genome to lineage specific gene expression remains poorly understood. To decipher …

Topologically associating domains (TADs) are integral to spatial genome organization,
instructing gene expression, and cell fate. Recently, several advances have uncovered roles …

Keratinocyte senescence contributes to skin ageing and epidermal dysfunction. According to
the existing knowledge, the transcription factor ΔNp63α plays pivotal roles in differentiation …

Gene expression programs are regulated by enhancers which act in a context-specific
manner, and can reside at great distances from their target genes. Extensive three …

Lymphocyte development consists of sequential and mutually exclusive cell states of
proliferative selection and antigen receptor gene recombination. Transitions between each …