Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease
(AD). Previous evidence suggested disruptions of multiple stages of the autophagy …

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …

Significance: Autophagy is a self-degrading process that determines cell fate in response to
various environmental stresses. In contrast to autophagy-mediated cell survival, the signals …

Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Chimeric antigen receptor (CAR) T cell therapy is used in treating human hematological
malignancies, but its efficacy is limited by T cell exhaustion (TEX). TEX arises at the expense …

The nuclear lamins are polymeric intermediate filament proteins that scaffold the nucleus
and organize the genome in nearly all eukaryotic cells. This review focuses on the dynamic …

Abstract Sirtuin 3 (Sirt3), a mitochondrial deacetylase, regulates mitochondrial redox
homeostasis and autophagy and is involved in physiological and pathological processes …

Mammalian aging is characterized by the progressive loss of tissue function and increased
risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this …