[HTML][HTML] Sterubin protects against chemically-induced Alzheimer's disease by reducing biomarkers of inflammation-IL-6/IL-β/TNF-α and oxidative stress-SOD/MDA in …
Sterubin, a flavanone is an active chemical compound that possesses neuroprotective
activity. The current investigation was intended to assess the sterubin effect in scopolamine …
activity. The current investigation was intended to assess the sterubin effect in scopolamine …
Lycopodiastrum casuarinoides: An overview of their phytochemicals, biological activities, structure-activity relationship, biosynthetic pathway and 13C NMR data
Y Liu, Q Wang, Z Xie, DK Zheng, J Li, GS Tan - Fitoterapia, 2023 - Elsevier
Huperzine A, a lycodine-type alkaloid, exhibits potent inhibitory activity against
acetylcholinesterase (AChE) and has been utilized to treat neurodegenerative diseases' …
acetylcholinesterase (AChE) and has been utilized to treat neurodegenerative diseases' …
Design, synthesis and molecular docking simulation of oxindole-based derivatives with dual VEGFR-2 and cholinesterase inhibitory activities
AM Srour, DH Dawood, ES Nossier… - Journal of Molecular …, 2023 - Elsevier
Oxindole-based compounds are deemed to be an interesting scaffold with significant
VEGFR-2 and cholinesterase inhibitory properties. Regarding the studies that displayed the …
VEGFR-2 and cholinesterase inhibitory properties. Regarding the studies that displayed the …
Some bioactivities of isolated apigenin-7-O-glucoside and luteolin-7-O-glucoside
In this study, we aimed to isolate compounds from Stachys lavandulifolia (Lamiaceae) by
chromatographic methods and perform tyrosinase, acetylcholinesterase …
chromatographic methods and perform tyrosinase, acetylcholinesterase …
Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation
G Zhong, J Guo, C Pang, D Su, C Tang, L Jing… - Bioorganic …, 2023 - Elsevier
Cholinesterase and monoamine oxidase are potential targets for the therapy of Alzheimer's
disease. A series of novel AP2238-clorgiline hybrids as multi-target agents were designed …
disease. A series of novel AP2238-clorgiline hybrids as multi-target agents were designed …
Discovery of novel dual acetylcholinesterase and butyrylcholinesterase inhibitors using machine learning and structure-based drug design
Abstract Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucial targets
that catalyse the breakdown of acetylcholine (ACh) and are implicated in the pathogenesis …
that catalyse the breakdown of acetylcholine (ACh) and are implicated in the pathogenesis …
Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S‐transferase inhibitors
MO Karaytuğ, N Balcı, F Türkan… - … of Biochemical and …, 2023 - Wiley Online Library
Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a
naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous …
naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous …
Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The …
C Marcucci, M Rademacher, F Kamecki, V Pastore… - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder whose pathophysiology includes
the abnormal accumulation of proteins (eg, β-amyloid), oxidative stress, and alterations in …
the abnormal accumulation of proteins (eg, β-amyloid), oxidative stress, and alterations in …
Discovery of new, highly potent and selective inhibitors of BuChE-design, synthesis, in vitro and in vivo evaluation and crystallography studies
D Panek, A Pasieka, G Latacz, P Zaręba… - European Journal of …, 2023 - Elsevier
The symptomatic and disease-modifying effects of butyrylcholinesterase (BuChE) inhibitors
provide an encouraging premise for researching effective treatments for Alzheimer's …
provide an encouraging premise for researching effective treatments for Alzheimer's …
Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure–Activity Relationship
The multifaceted nature of Alzheimer's disease (AD) indicates the need for multitargeted
agents as potential therapeutics. Both cholinesterases (ChEs), acetylcholinesterase (AChE) …
agents as potential therapeutics. Both cholinesterases (ChEs), acetylcholinesterase (AChE) …