The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

The inflammasome is a protein complex composed of a variety of proteins in cells and which
participates in the innate immune response of the body. It can be activated by upstream …

Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

Background Ischemic stroke is a leading cause of permanent disability and death globally.
The nucleotide‐biding oligomaerization domain (NOD)‐like receptor family pyrin domain …

Background: Neuroinflammation plays extremely crucial roles in the neurological damage
mediated by ischemic stroke. TRIM29 (tripartite motif containing 29) has previously been …

Increasingly prevalent acute and chronic human brain diseases are scourges for the elderly.
Besides the lack of therapies, these ailments share a neuroinflammation that is …

The pivotal role of inflammation in the pathophysiology of heart-failure (HF) development
and progression has long been recognized. High blood levels of pro-inflammatory and …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Clinical and experimental studies highlighted the complex role of the immune system in the …

Activation of inflammasomes—immune system receptor sensor complexes that selectively
activate inflammatory responses—has been associated with diverse human diseases, and …

Background Ischemic stroke immediately evokes a strong neuro-inflammatory response
within the vascular compartment, which contributes to primary infarct development under …