Harnessing real-world evidence to advance cancer research

M Tang, SA Pearson, RJ Simes, BH Chua - Current Oncology, 2023 - mdpi.com
Randomized controlled trials (RCTs) form a cornerstone of oncology research by generating
evidence about the efficacy of therapies in selected patient populations. However, their …

[HTML][HTML] Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults–an AGePOP review

C Demeester, D Robins, AE Edwina, J Tournoy… - European Journal of …, 2023 - Elsevier
The older population consisting of persons aged 65 years or older is the fastest-growing
population group and also the major consumer of pharmaceutical products. Due to the …

Chemotherapy-related toxic effects and Quality of Life and Physical Functioning in older patients

JC Baltussen, NA de Glas, Y van Holstein… - JAMA Network …, 2023 - jamanetwork.com
Importance Although older patients are at increased risk of developing grade 3 or higher
chemotherapy-related toxic effects, no studies, to our knowledge, have focused on the …

Developing sustainable cancer and aging programs

T Hsu, R Elias, K Swartz, A Chapman - American Society of Clinical …, 2023 - ascopubs.org
Geriatric assessment (GA) has been shown to decrease toxicity from systemic therapy,
improve completion of chemotherapy, and reduce hospitalizations in older adults with …

Frailty assessment tools predict perioperative outcome in elderly patients with endometrial cancer better than age or BMI alone: a retrospective observational cohort …

K Anic, F Flohr, MW Schmidt, S Krajnak… - Journal of cancer …, 2023 - Springer
Objective Five commonly used global health assessment tools have been evaluated to
identify and assess the preoperative frailty status and its relationship with perioperative in …

Time trends in treatment patterns and survival of older patients with synchronous metastatic colorectal cancer in the Netherlands: A population‐based study

JC Baltussen, NA de Glas, GJ Liefers… - … Journal of Cancer, 2023 - Wiley Online Library
New treatment strategies have improved survival of metastatic colorectal cancer in trials.
However, it is not clear whether older patients benefit from these novel therapies, as they are …

Impact of COVID-19 pandemic on older cancer patients: proposed solution by the International Geriatric Radiotherapy Group

NP Nguyen, UL Karlsson, D Lehrman… - Frontiers in …, 2023 - frontiersin.org
Older cancer patients are disproportionally affected by the Coronavirus 19 (COVID-19)
pandemic. A higher rate of death among the elderly and the potential for long-term disability …

Associations of the 2018 World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) cancer prevention recommendations with stages of …

AS Kværner, AR Andersen, HB Henriksen… - Cancer …, 2023 - Wiley Online Library
Background While adherence to cancer prevention recommendations is linked to lower risk
of colorectal cancer (CRC), few have studied associations across the entire spectrum of …

[HTML][HTML] FOxTROT2: innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with …

JR Platt, OM Todd, P Hall, Z Craig, A Quyn, M Seymour… - ESMO open, 2023 - Elsevier
Treating older adults with cancer is increasingly important in modern oncology practice.
However, we currently lack the high-quality evidence needed to guide optimal management …

The effect of adjuvant radiotherapy after breast-conserving surgery in elderly women with T1-2N0 estrogen receptor-negative breast cancer

C Chen, R Wang, B Wang, Y Wu, J Jiang - Plos one, 2023 - journals.plos.org
Purpose To evaluate whether adjuvant radiotherapy (RT) following breast-conserving
surgery (BCS) results in better survival among women≥ 70 years with T1-2N0 estrogen …