Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?
B Zingales, AM Macedo - Life, 2023 - mdpi.com
Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking
genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity …
genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity …
Revisiting epidemiology of leishmaniasis in Central Asia: lessons learnt
V Yurchenko, DS Chistyakov, LV Akhmadishina… - Parasitology, 2023 - cambridge.org
In this work we reviewed historical and recent data on Leishmania spp. infection combining
data collected in Turkmenistan, Uzbekistan, Kazakhstan, Kyrgyzstan, Iran, China and …
data collected in Turkmenistan, Uzbekistan, Kazakhstan, Kyrgyzstan, Iran, China and …
Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics
African trypanosomes proliferate as bloodstream forms (BSFs) and procyclic forms in the
mammal and tsetse fly midgut, respectively. This allows them to colonise the host …
mammal and tsetse fly midgut, respectively. This allows them to colonise the host …
Emerging compounds and therapeutic strategies to treat infections from Trypanosoma brucei: an overhaul of the last 5-years patents
F Melfi, S Carradori, C Campestre… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Human African Trypanosomiasis is a neglected disease caused by
infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are …
infection from parasites belonging to the Trypanosoma brucei species. Only six drugs are …
Exploration of seryl tRNA synthetase to identify potent inhibitors against leishmanial parasites
Aminoacyl-tRNA synthetases are crucial enzymes for cellular protein metabolism and have
been considered as an attractive target for development of new antimicrobials. In the current …
been considered as an attractive target for development of new antimicrobials. In the current …
[HTML][HTML] Preliminary Information of Iranian Lizard Leishmania Promastigote Transcriptome Sequencing by Next Generation Sequencing (NGS) Method
F Ehya, S Kalantari, M Bandehpour… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Background: A lizard Leishmania has been isolated from a lizard (Agama agilis) in Iran. Its
genome sequence has not been determined, so far. Methods: The study was done at Shahid …
genome sequence has not been determined, so far. Methods: The study was done at Shahid …
Genomes of Endotrypanum monterogeii from Panama and Zelonia costaricensis from Brazil: Expansion of Multigene Families in Leishmaniinae Parasites That Are Close …
PO Tullume-Vergara, KYO Caicedo, JFC Tantalean… - Pathogens, 2023 - mdpi.com
The Leishmaniinae subfamily of the Trypanosomatidae contains both genus Zelonia
(monoxenous) and Endotrypanum (dixenous). They are amongst the nearest known …
(monoxenous) and Endotrypanum (dixenous). They are amongst the nearest known …
Refinement of Leishmania donovani Genome Annotations in the Light of Ribosome-Protected mRNAs Fragments (Ribo-Seq Data)
A Sánchez-Salvador, S González-de la Fuente… - Genes, 2023 - mdpi.com
Advances in next-generation sequencing methodologies have facilitated the assembly of an
ever-increasing number of genomes. Gene annotations are typically conducted via …
ever-increasing number of genomes. Gene annotations are typically conducted via …
Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery
L Urán Landaburu, M Didier Garnham… - Biochemical Society …, 2023 - portlandpress.com
Trypanosomatids are protozoan parasites that cause human and animal neglected
diseases. Despite global efforts, effective treatments are still much needed. Phenotypic …
diseases. Despite global efforts, effective treatments are still much needed. Phenotypic …
Functional differentiation of Sec13 paralogues in the euglenozoan protists
D Faktorová, K Záhonová, C Benz… - Open …, 2023 - royalsocietypublishing.org
The β-propeller protein Sec13 plays roles in at least three distinct processes by virtue of
being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore …
being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore …