Pannexin channels play fundamental roles in regulating inflammation and have been
implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the …

Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal
excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to …

ATP is well established as a transmitter and modulator in the peripheral and central nervous
system. While conventional exocytotic release of ATP at synapses occurs, this transmitter is …

Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane
channels permeable to anions and moderate-sized signaling molecules (eg, ATP …

Pannexin 1 (PANX1) is a widely expressed large-pore ion channel located in the plasma
membrane of almost all vertebrate cells. It possesses a unique ability to act as a conduit for …

Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence
has been reported about the role of this nucleotide and purinergic receptors, in particular …

Cannabis legalization prompted the dilemma if plant-derived recreational drugs can have
therapeutic potential and, consequently, how to address their regulation and safe …