Amyotrophic lateral sclerosis is one of several chronic neurodegenerative conditions in
which mitochondrial abnormalities are posited to contribute to disease progression …

The World Health Organization (WHO) stated that ensuring access to effective and optimal
treatment is a key component to eradicate tuberculosis (TB) through the End TB Strategy …

Objective The mitochondrial phenotype, governed by the balance of fusion-fission, is a key
determinant of energy metabolism. The inner and outer mitochondrial membrane (IMM) …

Mitochondrial dysfunctions are widely afflicted in central nervous system (CNS) disorders
with minimal understanding on how to improve mitochondrial homeostasis to promote …

Inner mitochondrial membrane fusion and cristae shape depend on optic atrophy protein 1,
OPA1. Mutations in OPA1 lead to autosomal dominant optic atrophy (ADOA), an important …

Dominant optic atrophy (DOA) is an inherited disease that leads to the loss of retinal
ganglion cells (RGCs), the projection neurons that relay visual information from the retina to …

Alcoholic myopathy is caused by chronic consumption of alcohol (ethanol) and is
characterized by weakness and atrophy of skeletal muscle. Regular exercise is one of the …

Dominant optic atrophy is an optic neuropathy with varying clinical symptoms and
progression. A severe disorder is associated with certain OPA1 mutations and includes …

It is unclear how skeletal muscle metabolism and mitochondrial function adapt to long
duration bed rest and whether changes can be prevented by nutritional intervention. The …

Mitochondrial optic neuropathies have a leading role in the field of mitochondrial medicine
ever since 1988, when the first mutation in mitochondrial DNA was associated with Leber's …