Malignancy‐associated immune responses: Lessons from human inborn errors of immunity

A Aliyath, A Eni‐Olotu, N Donaldson, P Trivedi - Immunology, 2023 - Wiley Online Library
It is widely understood that cancer is a significant cause of morbidity and mortality
worldwide. Despite numerous available treatments, prognosis for many remains poor, thus …

Dendritic cells in inborn errors of immunity

S Gupta, A Agrawal - Frontiers in Immunology, 2023 - frontiersin.org
Dendritic cells (DCs) are crucial cells for initiating and maintaining immune response. They
play critical role in homeostasis, inflammation, and autoimmunity. A number of molecules …

Scalable GMP-compliant gene correction of CD4+ T cells with IDLV template functionally validated in vitro and in vivo

C Asperti, D Canarutto, S Porcellini, F Sanvito… - … Therapy-Methods & …, 2023 - cell.com
Hyper-IgM1 is a rare X-linked combined immunodeficiency caused by mutations in the
CD40 ligand (CD40LG) gene with a median survival of 25 years, potentially treatable with in …