Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays

H Chai, F Xu, J Wang, Y Zhang, X Xie, H Zhou… - Chemico-biological …, 2023 - Elsevier
Abstract CC chemokine receptor 3 (CCR3) plays important roles in atopic dermatitis (AD)
and other related allergic diseases. Activation of CCR3 receptor signaling pathways …

Studying allosteric regulation of chemokines and antagonists using a nanoscale hCCR3 receptor sensor

X Wang, D Lu, D Peng, D Liu, Y Liu, Y Liu, W Xu… - International Journal of …, 2023 - Elsevier
Abstract CC chemokine receptor-3 (hCCR3), a G protein-coupled receptor (GPCR)
expressed predominantly on eosinophils, is an important drug target. However, it was …

Chemokine receptors in GtoPdb v. 2023.1

F Bachelerie, A Ben-Baruch, AM Burkhardt… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on
Chemokine Receptors [438, 437, 32]) comprise a large subfamily of 7TM proteins that bind …