Endometrial cancer (EC) is one of the most common gynecological malignancies in Western
countries. Traditionally, loco-reginal dissemination and histological characteristics are the …

Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …

Background Standard first-line chemotherapy for endometrial cancer is paclitaxel plus
carboplatin. The benefit of adding pembrolizumab to chemotherapy remains unclear …

Introduction Many advances in the understanding of the pathologic and molecular features
of endometrial cancer have occurred since the FIGO staging was last updated in 2009 …

Background Risk-assessment of endometrial cancer (EC) is based on clinicopathological
factors and molecular subgroup. It is unclear whether adding hormone receptor expression …

DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …

Background Endometrial cancer can be molecularly classified into POLE mut, mismatch
repair deficient (MMRd), p53 abnormal (p53abn), and no specific molecular profile (NSMP) …

Endometrial diseases are the most common gynecological pathologies in Western
Countries. Among these, endometrial cancer (EC) is the most common gynecological …

PURPOSE The molecular classification of endometrial cancer (EC) has proven to have
prognostic value and is predictive of response to adjuvant chemotherapy. Here, we …

Endometrial diseases are the most common gynecological pathologies in Western
Countries. Among these, endometrial cancer (EC) is the most common gynecological …