Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations
X Liao, Y Han, C Shen, J Liu, Y Wang - Phytotherapy Research, 2023 - Wiley Online Library
Abstract Background and Aim Hypertension is a major global health problem that causes
target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms …
target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms …
Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease
Alzheimer's disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …
[HTML][HTML] Enhanced cerebral hemodynamics and cognitive function via knockout of dual-specificity protein phosphatase 5
Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are
neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an …
neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an …
[HTML][HTML] Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
J Huang, ZF Xu, F Liu, AN Song, H Su, C Zhang - Iscience, 2023 - cell.com
Summary Minichromosome maintenance 6 (MCM6) has been implicated in the progression
of various malignant tumors; however, its exact physiological function in kidney diseases …
of various malignant tumors; however, its exact physiological function in kidney diseases …
[HTML][HTML] Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats
Vascular aging influences hemodynamics, elevating risks for vascular diseases and
dementia. We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and …
dementia. We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and …
Screening and identification of key biomarkers in diabetic kidney disease and its complications: Evidence from bioinformatics and next generation sequencing data …
B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Diabetic patients are prone to diabetic kidney disease (DKD), which may cause
cardiovascular damage, hypertension and obesity, and reduce quality of life. As a result, the …
cardiovascular damage, hypertension and obesity, and reduce quality of life. As a result, the …