Role of thymic stromal lymphopoietin in allergy and beyond

R Ebina-Shibuya, WJ Leonard - Nature Reviews Immunology, 2023 - nature.com
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

The role of TSLP in atopic dermatitis: from pathogenetic molecule to therapeutical target

J Luo, Z Zhu, Y Zhai, J Zeng, L Li… - Mediators of …, 2023 - Wiley Online Library
Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration,
characterized by skin barrier dysfunction, immune response dysregulation, and skin …

“Input/output cytokines” in epidermal keratinocytes and the involvement in inflammatory skin diseases

S Morizane, T Mukai, K Sunagawa… - Frontiers in …, 2023 - frontiersin.org
Considering the role of epidermal keratinocytes, they occupy more than 90% of the
epidermis, form a physical barrier, and also function as innate immune barrier. For example …

TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis

Y Rochman, M Kotliar, N Ben-Baruch Morgenstern… - Science …, 2023 - science.org
The cytokine thymic stromal lymphopoietin (TSLP) mediates type 2 immune responses, and
treatments that interfere with TSLP activity are in clinical use for asthma. Here, we …

A four-part guide to lung immunology: Invasion, inflammation, immunity, and intervention

I Gopallawa, R Dehinwal, V Bhatia, V Gujar… - Frontiers in …, 2023 - frontiersin.org
Lungs are important respiratory organs primarily involved in gas exchange. Lungs interact
directly with the environment and their primary function is affected by several inflammatory …

Severe asthmatic responses: the impact of TSLP

E Theofani, A Tsitsopoulou, I Morianos… - International Journal of …, 2023 - mdpi.com
Asthma is a chronic inflammatory disease that affects the lower respiratory system and
includes several categories of patients with varying features or phenotypes. Patients with …

T cell co-stimulatory and co-inhibitory pathways in atopic dermatitis

C Zheng, Y Shi, Y Zou - Frontiers in Immunology, 2023 - frontiersin.org
The use of immune checkpoint inhibitors (ICIs) targeting the T cell inhibitory pathways has
revolutionized cancer treatment. However, ICIs might induce progressive atopic dermatitis …

Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake

T Kasuya, S Tanaka, J Tamura, K Etori, J Shoda… - Scientific Reports, 2023 - nature.com
Epithelial cells control a variety of immune cells by secreting cytokines to maintain tissue
homeostasis on mucosal surfaces. Regulatory T (Treg) cells are essential for immune …

Increased expression of long-isoform thymic stromal lymphopoietin is associated with rheumatoid arthritis and fosters inflammatory responses

W Li, C Liao, J Du, J Hu, L Wang, X Song, Z He… - Frontiers in …, 2023 - frontiersin.org
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that is involved in the
pathogenesis of inflammatory diseases and asthma, but the expression and biological …

Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth

T Kanninen, L Tao, R Romero, Y Xu… - Human Immunology, 2023 - Elsevier
The aim of this study was to establish the role of thymic stromal lymphopoietin (TSLP) in the
intra-amniotic host response of women with spontaneous preterm labor (sPTL) and birth …