Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation
and cell death, HMGB1 can function as an alarm protein (alarmin) or damage-associated …

The concept of immunological memory was demonstrated in antiquity when protection
against re-exposure to pathogens was observed during the plague of Athens …

Objective We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis
flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming …

Psoriatic arthritis (PsA) is a chronic and painful inflammatory immune-mediated disease. It
affects up to 40% of people with psoriasis and it is associated with several comorbidities …

Background: Methotrexate (MTX), sulfonamides, hydroxychloroquine, and leflunomide have
consistently resulted in remission with relatively mild to moderate adverse effects in patients …

Toll-like receptors (TLRs) are a well-characterized family of cell-bound pattern recognition
receptors able to identify and respond to conserved structures of external microorganisms or …

In this investigation, the quality of consumer-grade seeds of Nigella sativa was assessed
using TQ (TQ) as a standard compound. Assessment of the seeds was based on the amount …

In this second chapter of the “Autoimmunity” part, the pathogenetic role of DAMPs and
SAMPs in systemic autoimmune diseases is presented by referring to two prototypical …

Abstract [eng] This study evaluated the role of sociodemographic, clinical, ultrasound, and
laboratory variables, which are usually assessed in everyday rheumatologist clinical …