Redirecting E3 ligases to neo-substrates, leading to their proteasomal disassembly, known
as targeted protein degradation (TPD), has emerged as a promising alternative to traditional …

We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal
variants from genetic association data (individual-level or summary data). mvSuSiE learns …

Rationale & Objective Focal segmental glomerulosclerosis (FSGS) is a major cause of
pediatric nephrotic syndrome, and African Americans exhibit an increased risk for …

Background Short-term clinical trials have shown the cholesterol-lowering potentials of
phytosterols, but their impacts on cardiovascular disease (CVD) remain controversial. This …

Human iron nutrition is a result of interplays between genetic and environmental factors.
However, there has been scarcity of data on the genetic variants associated with altered iron …

Background Early detection of cognitive impairment in patients undergoing ileostomy for
colorectal cancer may help improve patient outcomes and quality of life. Identifying risk …

Abstract Aims Hemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes.
However, estimates of the heritability of HbA1c and glucose levels are different. Therefore …

This dissertation examines significant risk loci identified through GWAS for neuropsychiatric
illness to prioritize causal variants and genes for future validation in functional assays. This …

Immune thrombocytopenia (ITP) is widely accepted as an acquired autoimmune disorder
characterised by autoantibody-induced platelet destruction. A New Zealand family with a …

US11542493B2 - Targeting BCL11A distal regulatory elements for fetal hemoglobin
reinduction - Google Patents US11542493B2 - Targeting BCL11A distal regulatory …