Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

Predictive biomarkers of response are essential to effectively guide targeted cancer
treatment. Ataxia telangiectasia and Rad3-related kinase inhibitors (ATRi) have been shown …

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell
lymphoma most reported in Asia. We performed a comprehensive clinical, pathological and …

Genetic and epigenetic alterations play central roles in shaping the immunosuppressive
tumor microenvironment (TME) to evade immune surveillance. The previous study shows …

Biallelic inactivation of the tumour suppressor gene Von Hippel–Lindau (VHL) occurs in the
vast majority of clear cell renal cell carcinoma (ccRCC) instances, disrupting cellular oxygen …

The cell-cycle checkpoint kinase WEE1 is emerging as a therapeutic target for cancer
treatment. However, how its catalytic activity is regulated remains poorly understood, and …

Background Prostate cancer is a leading cause of cancer-related deaths among men
worldwide. Docetaxel chemotherapy has proven effective in improving overall survival in …

Abstract SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently
linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer …

The covalent modification of histones is critical for many biological functions in mammals,
including gene regulation and chromatin structure. Posttranslational histone modifications …