Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Compounds containing an Ssingle bondF bond have garnered intense interest in the
chemical and biological literature. In particular, sulfonyl fluorides (RSO 2 F) are commonly …

Sulfur (VI) fluoride exchange (SuFEx) gives rise to a plethora of high-valent sulfur linkages;
however, the availability of (aliphatic) sulfonyl fluoride manifolds lag behind, owing to the …

All fluorochemicals—including elemental fluorine and nucleophilic, electrophilic, and radical
fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and …

Advances in chemoproteomic technology have revealed covalent interactions between
small molecules and protein nucleophiles, primarily cysteine, on a proteome-wide scale …

Sulfinates are important lynchpin intermediates in pharmaceutical production; however, their
synthesis via photoredox catalysis is challenging because of their facile oxidation. We …

A practical electrochemically driven method for fluorosulfonylation of both aryl and alkyl
thianthrenium salts has been disclosed. The strategy does not need external redox reagents …

Sulfonyl and sulfonimidoyl fluorides are versatile substrates in organic synthesis and
medicinal chemistry. However, they have been exclusively used as S (VI)+ electrophiles for …

An electroreductive strategy for radical hydroxyl fluorosulfonylation of alkenes with sulfuryl
chlorofluoride and molecular oxygen from air is described. This mild protocol displays …

Recent advances in the synthesis of sulfur (VI)-fluorides has enabled incredible growth in
their application in biomolecular chemistry. This review aims to serve as a primer …