CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
[HTML][HTML] Research progress in calcitonin gene-related peptide and bone repair
Q Wang, H Qin, J Deng, H Xu, S Liu, J Weng, H Zeng - Biomolecules, 2023 - mdpi.com
Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …
[HTML][HTML] The vascular role of CGRP: A systematic review of human studies
MAM Al-Karagholi, V Kalatharan, PS Fagerberg… - Frontiers in …, 2023 - frontiersin.org
Intravenous infusion of human alpha calcitonin gene-related peptide (h-α-CGRP) has been
applied to explore migraine pathogenesis and cerebral hemodynamics during the past three …
applied to explore migraine pathogenesis and cerebral hemodynamics during the past three …
[HTML][HTML] Calcitonin gene-related peptide: a potential protective agent in cerebral ischemia–reperfusion injury
J Xiong, Z Wang, J Bai, K Cheng, Q Liu… - Frontiers in Neuroscience, 2023 - frontiersin.org
Ischemic stroke is the most common type of cerebrovascular disease with high disability and
mortality rates, which severely burdens patients, their families, and society. At present …
mortality rates, which severely burdens patients, their families, and society. At present …
[HTML][HTML] Pharmacological profile of the purinergic P2Y receptors that modulate, in response to ADPβS, the vasodepressor sensory CGRPergic outflow in pithed rats
AD Miguel-Martínez, J Linares-Bedolla… - Pharmaceuticals, 2023 - mdpi.com
Calcitonin gene-related peptide (CGRP), an endogenous neuropeptide released from
perivascular sensory nerves, exerts a powerful vasodilatation. Interestingly, adenosine …
perivascular sensory nerves, exerts a powerful vasodilatation. Interestingly, adenosine …
[HTML][HTML] Calcitonin Gene-Related Peptide Systemic Effects: Embracing the Complexity of Its Biological Roles—A Narrative Review
A Bonura, N Brunelli, M Marcosano… - International Journal of …, 2023 - mdpi.com
The calcitonin gene-related peptide (CGRP) is a neuropeptide widely distributed throughout
the human body. While primarily recognized as a nociceptive mediator, CGRP antagonists …
the human body. While primarily recognized as a nociceptive mediator, CGRP antagonists …
[PDF][PDF] Visual hypersensitivity in migraine patients treated with monoclonal anti-CGRP (receptor) antibodies
S de Vries Lentsch… - Treatment with …, 2023 - scholarlypublications …
Visual hypersensitivity in migraine patients treated with monoclonal anti-CGRP (receptor)
antibodies Page 103 Chapter 6 Visual hypersensitivity in migraine patients treated with …
antibodies Page 103 Chapter 6 Visual hypersensitivity in migraine patients treated with …
[PDF][PDF] Treatment ith anti-CGRP (receptor) antibodies for migraine: can e predict effecti eness?
S de Vries Lentsch - 2023 - scholarlypublications …
Migraine is a highly prevalent, primary headache disorder. It is estimated that 15% of the
world population suffers from migraine, representing a large socioeconomic burden. 1 The …
world population suffers from migraine, representing a large socioeconomic burden. 1 The …
[HTML][HTML] Blocking the CGRP receptor: differences across human vascular beds
T de Vries, DM Boucherie, A van den Bogaerdt… - Pharmaceuticals, 2023 - mdpi.com
Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been
developed for the treatment of migraine. Here, the effect of the small-molecule CGRP …
developed for the treatment of migraine. Here, the effect of the small-molecule CGRP …