The great immune escape: understanding the divergent immune response in breast cancer subtypes
Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …
Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis
The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …
Association of machine learning–based assessment of tumor-infiltrating lymphocytes on standard histologic images with outcomes of immunotherapy in patients with …
Importance Currently, predictive biomarkers for response to immune checkpoint inhibitor
(ICI) therapy in lung cancer are limited. Identifying such biomarkers would be useful to refine …
(ICI) therapy in lung cancer are limited. Identifying such biomarkers would be useful to refine …
[HTML][HTML] Artificial intelligence reveals features associated with breast cancer neoadjuvant chemotherapy responses from multi-stain histopathologic images
Advances in computational algorithms and tools have made the prediction of cancer patient
outcomes using computational pathology feasible. However, predicting clinical outcomes …
outcomes using computational pathology feasible. However, predicting clinical outcomes …
[HTML][HTML] The significance of SPP1 in lung cancers and its impact as a marker for protumor tumor-associated macrophages
E Matsubara, H Yano, C Pan, Y Komohara, Y Fujiwara… - Cancers, 2023 - mdpi.com
Simple Summary Macrophages that infiltrate the cancer microenvironment are referred to as
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …
Role of immunotherapy in breast cancer
SL Jacob, LA Huppert, HS Rugo - JCO Oncology Practice, 2023 - ascopubs.org
The advent of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has
revolutionized the treatment of solid tumor malignancies. In breast cancer, the most robust …
revolutionized the treatment of solid tumor malignancies. In breast cancer, the most robust …
[HTML][HTML] Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma …
Background Recent advances in digital pathology have enabled accurate and standardised
enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a …
enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a …
[HTML][HTML] Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer
The utility of spatial immunobiomarker quantitation in prognostication and therapeutic
prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with …
prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with …
[HTML][HTML] Antimicrobial exposure is associated with decreased survival in triple-negative breast cancer
JD Ransohoff, V Ritter, N Purington, K Andrade… - Nature …, 2023 - nature.com
Antimicrobial exposure during curative-intent treatment of triple-negative breast cancer
(TNBC) may lead to gut microbiome dysbiosis, decreased circulating and tumor-infiltrating …
(TNBC) may lead to gut microbiome dysbiosis, decreased circulating and tumor-infiltrating …
[HTML][HTML] PD-L1 expression as biomarker of efficacy of PD-1/PD-L1 checkpoint inhibitors in metastatic triple negative breast cancer: A systematic review and meta …
M Khan, K Du, M Ai, B Wang, J Lin, A Ren… - Frontiers in …, 2023 - frontiersin.org
Background Inhibitors of programmed cell death 1 (PD-1)/programmed cell death ligand 1
(PD-L1) checkpoint have been approved for metastatic triple negative breast cancer …
(PD-L1) checkpoint have been approved for metastatic triple negative breast cancer …