NF-κB transcription factors are critical regulators of innate and adaptive immunity and major
mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant …

Background Liver is a vital organ responsible for metabolizing and detoxifying both
endogenous and exogenous substances in the body. However, it is susceptible to damage …

Gene regulation plays a critical role in the cellular processes that underlie human health and
disease. The regulatory relationship between transcription factors (TFs), key regulators of …

Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes,
peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are …

The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous
cell types, including the inflammatory response, cell proliferation, survival, differentiation …

Ethnopharmacological relevance Licorice is a medicinal herb with a 2000-year history of
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …

Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in the western
world. Despite the positive clinical effects of new targeted therapies, CLL still remains an …

Simple Summary NF-κB transcription factors are leading modulators of innate immunity.
Recent investigations reveal their interplay with energetic metabolism as a central task of …

Epigenetic modifications regulate critical biological processes that play a pivotal role in the
pathogenesis of cancer. Enhancer of Zeste Homolog 2 (EZH2), a subunit of the Polycomb …

Spinal cord injury (SCI) is a type of central nervous system trauma that can lead to severe
nerve injury. Inflammatory reaction after injury is an important pathological process leading …