HD and SCA1: Tales from two 30-year journeys since gene discovery
LM Thompson, HT Orr - Neuron, 2023 - cell.com
One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …
expansion of unstable nucleotide repeats underlies a group of inherited neurological …
[HTML][HTML] Rodent Models of Huntington's Disease: An Overview
Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …
[HTML][HTML] The role of voltage-gated calcium channels in basal ganglia neurodegenerative disorders
BHM Correa, CR Moreira, ME Hildebrand… - Current …, 2023 - ncbi.nlm.nih.gov
Abstract Calcium (Ca 2+) plays a central role in regulating many cellular processes and
influences cell survival. Several mechanisms can disrupt Ca 2+ homeostasis to trigger cell …
influences cell survival. Several mechanisms can disrupt Ca 2+ homeostasis to trigger cell …
Variant RNAi
Provided herein are RNAi molecules including a first strand containing a guide sequence
and a second strand comprising a non-guide sequence where the non-guide sequence …
and a second strand comprising a non-guide sequence where the non-guide sequence …
Variant RNAi
CR O'riordan, A Palermo, B Richards… - US Patent …, 2023 - Google Patents
2020-06-22 Assigned to GENZYME CORPORATION reassignment GENZYME
CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …