Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Background Persons with toxic gain-of-function variants in the gene encoding
apolipoprotein L1 (APOL1) are at greater risk for the development of rapidly progressive …

The number of individuals with the sickle cell trait exceeds 300 million worldwide, making
sickle cell disease one of the most common monogenetic diseases globally. Because of the …

Two heterozygous missense variants (G1 and G2) of Apolipoprotein L1 (APOL1) found in
individuals of recent African ancestry can attenuate the severity of infection by some forms of …

It is critical to characterize the natural history of albuminuria in patients with sickle cell
anemia (SCA); however, these data are currently lacking and affecting evidence-based …

Nonadherence is common in individuals with sickle cell disease (SCD) on hydroxyurea
therapy and can be observed with waning improvements in hematologic parameters or …

The underlying mechanisms of disease in sickle cell disease (SCD) contribute to a
multifaceted nephropathy, commonly manifested as albuminuria. In severe SCD genotypes …

Síndrome nefrótica (SN) é a segunda causa mais frequente de doença renal estágio
terminal (DRET) na faixa etária pediátrica. Atualmente até 30% dos casos de SN congênita …

Background: Sickle cell disease is an inherited red blood cell disorder that affects
approximately 100,000 people in the USA and 25 million people worldwide. Vaso-occlusion …

Early in life, patients with sickle cell anemia are at high risk for the development of
hyposthenuria, enuresis, and hyperfiltration. Importantly, sickle cell patients are at risk for the …