Cell-free DNA-based liquid biopsies in neurology

H Gaitsch, RJM Franklin, DS Reich - Brain, 2023 - academic.oup.com
This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …

[HTML][HTML] Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications

V Vrablova, N Kosutova, A Blsakova, A Bertokova… - Biotechnology …, 2023 - Elsevier
This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …

Simultaneous ultra-sensitive detection of structural and single nucleotide variants using multiplex droplet digital PCR in liquid biopsies from children with …

C Arthur, C Jylhä, TD de Ståhl, A Shamikh, J Sandgren… - Cancers, 2023 - mdpi.com
Simple Summary Medulloblastoma is one of the most common types of brain tumors in
children. During and after treatment with surgery, chemotherapy, and/or radiotherapy …

Recent developments in blood biomarkers in neuro-oncology

JB Foster, MP Koptyra, SJ Bagley - Current Neurology and Neuroscience …, 2023 - Springer
Abstract Purpose of Review Given the invasive and high-risk nature of brain surgery, the
need for non-invasive biomarkers obtained from the peripheral blood is greatest in tumors of …

[HTML][HTML] Cerebrospinal Fluid biomarkers in pediatric brain tumors: A systematic review

KR Lehner, K Jiang, J Rincon-Torroella, R Perera… - Neoplasia, 2023 - Elsevier
Central nervous system (CNS) tumors are the leading cause of cancer death in pediatric
patients. Though these tumors typically require invasive surgical procedures to diagnose …

[HTML][HTML] Recent advances in the use of liquid biopsy to fight central nervous system tumors

CP Heming, P Niemeyer Filho, V Moura-Neto… - Cancer Treatment and …, 2023 - Elsevier
Brain tumors are considered one of the deadliest types of cancer, being challenging to treat,
especially due to the blood-brain barrier, which has been linked to treatment resistance. The …

From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients

B Grebstad Tune, H Sareen, B Powter… - Biomedicines, 2023 - mdpi.com
Genetic histone variants have been implicated in cancer development and progression.
Mutations affecting the histone 3 (H3) family, H3. 1 (encoded by HIST1H3B and HIST1H3C) …

BRAF Landscape and Its Implications among Patients with Pediatric Low-Grade Gliomas: A Comprehensive Review of the Literature

MA Fouda - Journal of Pediatric Neurology, 2023 - thieme-connect.com
Low-grade gliomas are the most common intracranial tumor in the pediatric population.
Pediatric low-grade gliomas represent a heterogeneous group of tumors. Genetic alterations …

[PDF][PDF] Clinical Application of Liquid Biopsy In CNS Tumors With Reference To Exosomes And Mirna

M Tenguria, V Rajput, M Gupta, N Sharma, S Gupta - researchgate.net
In most cases, it is difficult to make an earlier diagnosis of the Central nervous system (CNS)
tumour, which continues to be the most lethal cancer. Patients with chemo-resistance who …