Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Widespread use of contemporary antiretroviral therapy globally has transformed HIV
disease into a chronic illness associated with excess risk for disorders of the heart and …

Chronologic age is the dominant risk factor for coronary artery disease but the features of
aging promoting coronary artery disease are poorly understood. Advances in human …

The evolution of antiretroviral therapies (ART) has tremendously improved the life
expectancy of people living with human immunodeficiency virus (HIV)(PLWH), which is …

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …

PURPOSE Clonal hematopoiesis (CH), the expansion of clones in the hematopoietic
system, has been linked to different internal and external features such as aging, genetic …

Clonal hematopoiesis (CH) represents clonal expansion of mutated hematopoietic stem
cells detectable in the peripheral blood or bone marrow through next generation …

Background High and low birth weight are independently associated with increased
cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential …

Clonal hematopoiesis (CH) is defined by the presence of somatic mutations in
hematopoietic stem and progenitor cells (HSPC). CH is associated primarily with advancing …

Age is the most important risk factor for cardiovascular disease and appears to be more than
a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension …