Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Similar to their pivotal roles in nervous system development, neurons have emerged as
critical regulators of cancer initiation, maintenance, and progression. Focusing on nervous …

Immune checkpoint blockade (ICB) therapy targeting PD-1/PD-L1 has shown durable
clinical benefits in lung cancer. However, many patients respond poorly to ICB treatment …

Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …

In recent decades, various roles of the gut microbiota in physiological and pathological
conditions have been uncovered. Among the many interacting pathways between the host …

Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na+)
channels (VGSCs), and preclinical studies show that these medications reduce tumour …

Glioblastoma multiforme (GBM) is an aggressive form of adult brain tumor that can arise from
a low-grade astrocytoma. In recent decades, several new conventional therapies have been …

Recent preclinical studies have linked antidepressants (AD) to their potential anticancer
effects in multiple cancers, but the impact on lung cancer remains unclear. This meta …

Tricyclic antidepressant is an old and well-established therapeutic agent with a good safety
profile, making them an excellent candidate for repurposing. In light of the growing …

Background The co‐occurrence of depression and diabetes mellitus has been linked to an
increased risk of developing cancer. This study aimed to investigate whether depression …