Imaging mass spectrometry is a well-established technology that can easily and succinctly
communicate the spatial localization of molecules within samples. This review …

Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research
allowing analyzes from small samples and low concentrations. This review begins with a …

Abstract Three-dimensional (3D) cell spheroid models combined with mass spectrometry
imaging (MSI) enables innovative investigation of in vivo-like biological processes under …

Metabolic perturbation score-based mass spectrometry imaging (MPS-MSI) is proposed to
reveal the spatially resolved functional metabolic response associated with disease …

Deconvolution of potential drug targets of the central nervous system (CNS) is particularly
challenging because of the complicated structure and function of the brain. Here, a …

Spatial segmentation aims to find homogeneous/heterogeneous subgroups of spectra or ion
images in mass spectrometry imaging (MSI) data. The maps it generated inform researchers …

Imaging mass spectrometry (IMS) provides untargeted, highly multiplexed maps of
molecular distributions in tissue. Ion images are routinely presented as heatmaps and can …

Multicellular tumor spheroids embedded in collagen I matrices are common in vitro systems
for the study of solid tumors that reflect the physiological environment and complexities of …

Alzheimer's disease (AD) is the most common form of neurological dementia, specified by
extracellular β-amyloid plaque deposition, neurofibrillary tangles, and cognitive impairment …

The application of ambient mass spectrometry imaging “MSI” is expanding in the areas of
fundamental research on drug delivery and multiple phases of the process of identifying and …