The tetrahydroisoquinoline (THIQ) natural products constitute one of the largest families of
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …

Among the tetrahydroisoquinoline (THIQ) of natural products, a family of THIQ alkaloids has
the characteristics of similar biosynthetic pathway. Such THIQ alkaloids family mainly …

A formal total synthesis of ecteinascidin 743 and lurbinectedin is achieved. Key features
involve a Pictet–Spengler cyclization coupling of the tetrahydroisoquinoline and …

In connection with our studies of biologically active 1, 2, 3, 4-tetrahydroisoquinoline marine
natural products, we describe herein a useful intramolecular photoredox transformation of 7 …

Abstract Ecteinascidin 743 (Et-743), also known by the trade name Yondelis®, is the
pioneering marine natural product to be successfully developed as an antitumor drug …

Trabectedin and lurbinectedin are therapeutic antitumor pharmaceuticals approved by the
Food and Drug Administration for treating soft tissue sarcomas and metastatic small cell lung …

A new practical synthesis of Pt-650, zalypsis and renieramycin T is achieved by employing a
Pictet− Spengler cyclization coupling of the tetrahydroisoquinoline and phenylalaninol …

A series of tetrahydroisoquinoline derivatives were prepared and their antitumor activity was
studied against several human carcinoma cell lines, including Ketr3, BEL‐7402, BGC‐823 …

We report herein an asymmetric Pictet–Spengler reaction of α‐ketoesters. In the presence of
a catalytic amount of simple alanine‐derived squaramide and p‐nitrobenzoic acid, reaction …

A method for the construction of various thio-bridged compounds is developed using readily
available o-(trimethylsilyl) aryl triflates as a source of aryne precursor, catalyzed by simple …