The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Aging impairs tendon stem/progenitor cell function and tendon homeostasis, however,
effective treatments for aging‐induced tendon diseases are lacking. Exosomes are naturally …

Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Mitochondria are membrane-enclosed organelles with endosymbiotic origins, harboring
independent genomes and a unique biochemical reaction network. To perform their critical …

Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic
transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically …

Tumours exhibit notable metabolic alterations compared with their corresponding normal
tissue counterparts. These metabolic alterations can support anabolic growth, enable …

Our increased understanding of how key metabolic pathways are activated and regulated in
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …

The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …