Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Cellular oxidation–reduction (redox) systems, which encompass pro‐and antioxidant
molecules, are integral components of a plethora of essential cellular processes. Any …

Effective protein quality control (PQC), essential for cellular health, relies on spatial
sequestration of misfolded proteins into defined inclusions. Here we reveal the coordination …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Aggregation of tau into filamentous inclusions underlies Alzheimer's disease (AD) and
numerous other neurodegenerative tauopathies. The pathogenesis of tauopathies remains …

Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

Ribosomes interact with a variety of different protein biogenesis factors that guide newly
synthesized proteins to their native 3D shapes and cellular localization. Depending on the …

Molecular chaperones are proteins that assist in the (un) folding and (dis) assembly of other
macromolecular structures toward their biologically functional state in a non-covalent …

Heat-shock proteins are upregulated in cancer and protect several client proteins from
degradation. Therefore, they contribute to tumorigenesis and cancer metastasis by reducing …

Eukaryotes organize cellular contents into membrane-bound organelles and membrane-
less condensates, for example, protein aggregates. An unsolved question is why the …