Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

In diseases of the central nervous system, such as Alzheimer's disease (AD), Parkinson's
disease (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and …

Objective The objective is to summarize the knowledge on the epidemiology,
pathophysiology and management of secondary headache attributed to SARS-CoV-2 …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

Headache is one of the most prevalent, although often underreported, symptoms of
coronavirus disease 2019 (COVID-19). It is generally accepted that this symptom is a form of …

Migraine is a complicated neurological disorder affecting 6% of men and 18% of women
worldwide. Various mechanisms, including neuroinflammation, oxidative stress, altered …

Abstract Background and Purpose Headache disorders place a significant burden on the
healthcare system, being the leading cause of disability in those under 50 years. Novel …

Migraine is a major health burden worldwide with complex pathophysiology and multifarious
underlying mechanisms. One poorly understood issue concerns the early steps in the …

Abstract Background Patients diagnosed with New Daily Persistent Headache and
Persistent Post-Traumatic Headache belong to a heterogeneous group of primary and …

Neuropathic pain, a debilitating condition with unmet medical needs, can be charactarised
as hyperexcitability of nociceptive neurons caused by dysfunction of ion channels. Voltage …