The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

The reversible and precise temporal and spatial regulation of histone lysine
methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of …

The most common type of kidney cancer in adults is renal cell carcinoma (RCC), which
accounts for approximately 90% of cases. RCC is a variant disease with numerous …

During the last decades, male urogenital cancers (including prostate, renal, bladder and
testicular cancers) have become one of the most frequently encountered malignancies …

The tyrosine kinase inhibitor (TKI) cabozantinib might impede the growth of the sunitinib-
resistant cell lines by targeting MET and AXL overexpression in metastatic renal cell …

Background RCC1 functions as a pivotal guanine nucleotide exchange factor and was
reported to be involved in mitosis, the assembly of the nuclear envelope, nucleocytoplasmic …

Renal cell carcinoma (RCC), the most prevalent type of kidney cancer, is a significant cause
of cancer morbidity and mortality worldwide. Antiangiogenic tyrosine kinase inhibitors (TKIs) …

Renal cell carcinoma accounts for 2–3% of all cancers. It is difficult to diagnose early.
Recently, genome-wide studies have identified that histone methylation was one of the …

Background The enhancer of zeste homolog 2 (EZH2) plays an important role in the tumor
microenvironment (TME), and EZH2 in shaping the epigenetic landscape of CD8+ T cell fate …

Background In recent years, there have been great improvements in the therapy of renal cell
carcinoma. Nevertheless, the therapeutic effect varies significantly from person to person. To …