Carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex (CRAB) is one of
the top-priority pathogens for new antibiotic development. Unlike other antibiotic-resistant …

Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

Serratia marcescens is a ubiquitous bacterium from order Enterobacterales displaying a
high genetic plasticity that allows it to adapt and persist in multiple niches including soil …

Acinetobacter baumannii is increasingly associated with various epidemics, representing a
serious concern due to the broad level of antimicrobial resistance and clinical …

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …

Background Heteroresistance refers to subpopulation-mediated differential antimicrobial
susceptibility within a clonal bacterial population. Usually, it designates a resistant …

We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant
Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated …

Objectives Stenotrophomonas maltophilia (S. maltophilia), an opportunistic pathogen,
causes infection in patients undergoing immunosuppressive therapy, mechanical …

Appropriate antibiotic treatment for critically ill patients with serious Gram-negative infections
in the intensive care unit is crucial to minimize morbidity and mortality. Several new …

Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …