Harnessing the therapeutic potential of the stem cell secretome in neonatal diseases

S Tung, E Delavogia, A Fernandez-Gonzalez… - Seminars in …, 2023 - Elsevier
Preterm birth and intra-partum related complications account for a substantial amount of
mortality and morbidity in the neonatal period despite significant advancements in neonatal …

Factors influencing the efficacy of umbilical cord blood-derived cell therapy for perinatal brain injury

E Purcell, T Nguyen, M Smith, T Penny… - Stem cells …, 2023 - academic.oup.com
Introduction We have previously described preclinical literature which supports umbilical
cord blood-derived cell (UCBC) therapy as an efficacious treatment for perinatal brain injury …

[HTML][HTML] Neonatal asphyxia as an inflammatory disease: reactive oxygen species and cytokines

K Okazaki, S Nakamura, K Koyano, Y Konishi… - Frontiers in …, 2023 - frontiersin.org
Neonatologists resuscitate asphyxiated neonates by every available means, including
positive ventilation, oxygen therapy, and drugs. Asphyxiated neonates sometimes present …

The fate and prospects of stem cell therapy in the treatment of hypoxic–ischemic encephalopathy

BY Luo, HS Zhou, YF Sun, QX Xiao… - European Journal of …, 2023 - Wiley Online Library
Hypoxic–ischemic encephalopathy (HIE) is a leading cause of long‐term neurological
disability in neonates and adults. Despite emerging advances in supportive care, like the …

[HTML][HTML] Hypothermia combined with neuroprotective adjuvants shortens the duration of hospitalization in infants with hypoxic ischemic encephalopathy: Meta-analysis

A Ovcjak, R Pontello, SP Miller, HS Sun… - Frontiers in …, 2023 - frontiersin.org
Objective: Therapeutic hypothermia (TH) is the current standard of care for neonatal hypoxic-
ischemic encephalopathy (HIE), yet morbidity and mortality remain significant. Adjuvant …

[HTML][HTML] Umbilical cord blood-derived cell therapy for perinatal brain injury: a systematic review & meta-analysis of preclinical studies

T Nguyen, E Purcell, MJ Smith, TR Penny… - International Journal of …, 2023 - mdpi.com
Perinatal brain injury is a major contributor to long-term adverse neurodevelopment. There
is mounting preclinical evidence for use of umbilical cord blood (UCB)-derived cell therapy …

[HTML][HTML] Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities

T Nagamura-Inoue, F Nagamura - Inflammation and Regeneration, 2023 - Springer
Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of
somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively …

Progress in the treatment of neonatal hypoxic-ischemic encephalopathy with umbilical cord blood mononuclear cells

J Zhou, T Gao, W Tang, T Qian, Z Wang, P Xu… - Brain and …, 2023 - Elsevier
Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease among newborns,
which is a leading cause of neonatal death and permanent neurological sequelae …

[HTML][HTML] Comparison of Biological Characteristics of Human Umbilical Cord Wharton's Jelly-Derived Mesenchymal Stem Cells from Extremely Preterm and Term …

P Huang, X Qin, C Fan, M Wang, F Chen… - Tissue Engineering and …, 2023 - Springer
Background: Despite the progress in perinatal-neonatal medicine, complications of
extremely preterm infants continue to constitute the major adverse outcomes in neonatal …

Stem Cell Therapy in Neonatal Hypoxic-Ischemic Encephalopathy and Cerebral Palsy: a Bibliometric Analysis and New Strategy

QX Xiao, MJ Geng, YF Sun, Y Pi, LL Xiong - Molecular Neurobiology, 2023 - Springer
The aim of this study was to identify related scientific outputs and emerging topics of stem
cells in neonatal hypoxic-ischemic encephalopathy (NHIE) and cerebral palsy (CP) through …