Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

The mammalian lung has an enormous environmental-epithelial interface that is optimized
to accomplish the principal function of the respiratory system, gas exchange. One …

Alveolar epithelial type II cells (AT2s) together with AT1s constitute the epithelial lining of
lung alveoli. In contrast to the large flat AT1s, AT2s are cuboidal and smaller. In addition to …

A hallmark of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases is
dysregulated repair of the alveolar epithelium. The Hippo pathway effector transcription …

The human respiratory system, consisting of the airway and alveoli, is one of the most
complex organs directly interfaced with the external environment. The diverse epithelial cells …

Doxorubicin is a common chemotherapeutic agent in clinic, but myocardial toxicity limits its
use. Fibroblast growth factor (FGF) 10, a multifunctional paracrine growth factor, plays …

Exocrine acinar cells in salivary glands (SG) are critical for oral health and loss of functional
acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are …

Lung cancer has the highest incidence rate and mortality worldwide. Moreover, multiple
factors may cause heterogeneity in the efficacy of immunotherapy for lung cancer, and …

There is growing evidence suggesting that urban pollution has adverse effects on lung
health. However, how urban pollution affects alveolar mesenchymal and epithelial stem cell …

Background COPD is an incurable disease and a leading cause of death worldwide. In
mice, fibroblast growth factor (FGF) 10 is essential for lung morphogenesis, and in humans …