The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …

Osteoporosis screening, diagnosis, and treatment have gained much attention in the health
care community over the past 2 decades. During this time, creation of multispecialty …

Osteoporosis is a multifactorial disease influenced by genetic and environmental factors,
which contributes to an increased risk of bone fracture, but early diagnosis of this disease …

Background Although osteoarthritis (OA) is one of the most prevalent joint disorders,
effective biomarkers to diagnose OA are still unavailable. This study aimed to acquire some …

Abstract Purpose of Review The purpose of this review is to summarize the different roles of
the transcription factor SP7 in regulating bone formation and remodeling, discuss current …

Objective In this study, we aimed to establish the causal effects of lowering sclerostin, target
of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors. Methods …

Context Previous genome-wide association studies (GWASs) of bone mineral density (BMD)
were mainly conducted in Europeans. Objective To explore genetic variants that affect BMD …

Abstract Toll-like receptor-4 (TLR4) has been implicated in the development and
progression of diabetic osteoporosis. However, the mechanisms underlying TLR4-regulated …

Abstract Purpose of Review Recent advancements in “omics” technologies and
bioinformatics have afforded researchers new tools to study bone biology in an unbiased …

Introduction Global aging has made osteoporosis an increasingly serious public health
problem. Osteoporotic fractures seriously affect the quality of life of patients and increase …