In vivo CRISPR/Cas9 screening identifies Pbrm1 as a regulator of myeloid leukemia development in mice
CRISPR/Cas9 screening approaches are powerful tool for identifying in vivo cancer
dependencies. Hematopoietic malignancies are genetically complex disorders in which the …
dependencies. Hematopoietic malignancies are genetically complex disorders in which the …
Evidence for widespread existence of functional novel and non-canonical human transcripts
D Xu, L Tang, J Zhou, F Wang, H Cao, Y Huang… - BMC biology, 2023 - Springer
Background Fraction of functional sequence in the human genome remains a key
unresolved question in Biology and the subject of vigorous debate. While a plethora of …
unresolved question in Biology and the subject of vigorous debate. While a plethora of …
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors
V Dvorak, A Casiraghi, C Colas, A Koren, T Tomek… - Cell Chemical …, 2023 - cell.com
Despite being considered druggable and attractive therapeutic targets, most of the solute
carrier (SLC) membrane transporters remain pharmacologically underexploited. One of the …
carrier (SLC) membrane transporters remain pharmacologically underexploited. One of the …
[图书][B] Perks and Considerations when Targeting Functional Non-Coding Regions with CRISPR/CAS9
K Geng - 2023 - search.proquest.com
Since the CRISPR system was discovered as an adaptive immune response in prokaryotic
cells, the past decade has witnessed the engineering and deployment of CRISPR/Cas9 as …
cells, the past decade has witnessed the engineering and deployment of CRISPR/Cas9 as …