Background Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine
(chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in …

Colorectal cancer (CRC) is the third most common cancer in the USA and worldwide. In the
USA, nearly one-third of CRC cases are anatomically classified as rectal cancer. Over the …

Radiotherapy remains a common treatment modality for cancer despite skeletal
complications. However, there are currently no effective treatments for radiation-induced …

This discussion summarizes the NCCN Clinical Practice Guidelines for managing squamous
cell anal carcinoma, which represents the most common histologic form of the disease. A …

Aim Colorectal cancer survivors are one of the most rapidly growing groups of patients living
with and beyond cancer. In a national multidisciplinary setting, we have examined the extent …

The observed increased risk of fracture after cancer radiation therapy is presumably due to a
radiation‐induced reduction in whole‐bone strength. However, the mechanisms for impaired …

Malignant bone tumors are aggressive tumors, with a high tendency to metastasize, that are
observed most frequently in adolescents during rapid growth spurts. Pediatric patients with …

Background The purpose of this study was to assess the odds of developing medical and
surgical adverse events following total hip arthroplasty (THA) in patients who have a history …

In this study, we used micro-CT-based finite element analysis to investigate the
biomechanical effects of radiation on the microstructure and mechanical function of murine …

Background and Objectives: Damage to normal bone tissue following therapeutic irradiation
(IR) represents a significant concern, as IR-induced bone microenvironment disruption can …