Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

N Bolshette, H Ibrahim, H Reinke… - Nature Reviews …, 2023 - nature.com
A wide variety of liver functions are regulated daily by the liver circadian clock and via
systemic circadian control by other organs and cells within the gastrointestinal tract as well …

[HTML][HTML] Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity

H Chi, J Yang, G Peng, J Zhang, G Song, X Xie… - Frontiers in …, 2023 - frontiersin.org
Background Head and neck squamous cell carcinoma (HNSCC) is the most common head
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …

[HTML][HTML] Role of melatonin in cancer: effect on clock genes

C Rodríguez-Santana, J Florido… - International Journal of …, 2023 - mdpi.com
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that
generates rhythmic changes in many physiological processes. Increasing evidence links …

[HTML][HTML] CRS: a circadian rhythm score model for predicting prognosis and treatment response in cancer patients

Y Liu, S Guo, Y Sun, C Zhang, J Gan, S Ning… - Journal of Translational …, 2023 - Springer
Background Circadian rhythm regulates complex physiological activities in organisms. A
strong link between circadian dysfunction and cancer has been identified. However, the …

[HTML][HTML] Modeling the circadian control of the cell cycle and its consequences for cancer chronotherapy

C Leung, C Gérard, D Gonze - Biology, 2023 - mdpi.com
Simple Summary The circadian clock controls many physiological processes including the
cell division cycle. Healthy cells thus have a higher propensity to divide at certain times …

[HTML][HTML] Neural function of Bmal1: an overview

Y Zheng, L Pan, F Wang, J Yan, T Wang, Y Xia, L Yao… - Cell & Bioscience, 2023 - Springer
Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor
central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is …

N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1

JI Hearn, M Alhilali, M Kim, ML Kalev-Zylinska… - Platelets, 2023 - Taylor & Francis
Peripheral circadian clocks control cell proliferation and survival, but little is known about
their role and regulation in megakaryocytic cells. N-methyl-D-aspartate receptor (NMDAR) …

[HTML][HTML] The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia

E Murgo, E De Santis, F Sansico, V Melocchi… - Journal of Experimental …, 2023 - Springer
Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological
malignancy, characterized by restricted cellular subsets with asymmetrically enriched …

[HTML][HTML] “Time” for obesity-related cancer: The role of the circadian rhythm in cancer pathogenesis and treatment

C Miro, A Docimo, L Barrea, L Verde, S Cernea… - Seminars in Cancer …, 2023 - Elsevier
The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a
central and a peripheral clock, which influences the cycles of activities and sleep of an …

Interaction between environmental pollutants and cancer drug efficacy: Bisphenol A, Bisphenol A diglycidyl ether and Perfluorooctanoic acid reduce vincristine …

FA Lagunas‐Rangel, W Liu… - Journal of Applied …, 2023 - Wiley Online Library
Every day, we are exposed to many environmental pollutants that can enter our body
through different routes and cause adverse effects on our health. Epidemiological studies …