Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor
microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis and …

Background It has been reported that smoking history as a predictor of immunotherapy
efficacy in patients with advanced lung cancer, however, the underlying mechanisms of this …

Background Intervertebral disc degeneration (IVDD) is widely recognized as the primary
etiological factor underlying low back pain, often necessitating surgical intervention as the …

Abstract Background AURKA, Aurora kinase A encoding gene, is an important signaling hub
gene for mitosis. In recent years, AURKA has been implicated in the occurrence and …

Background Gliomas, originating from glial cells within the brain or spinal cord, are common
central nervous system tumors with varying degrees of malignancy that influence the …

Background Liver cancer is the sixth most commonly diagnosed cancer and the third leading
cause of cancer-related death worldwide. Hepatocellular carcinoma accounts for an …

Introduction Hepatocellular carcinoma (HCC) prevalence is rising annually, but the existing
treatment strategies are limited; therefore, it is crucial to explore new therapeutic …

Background Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine
malignancy, of which> 40% present with glucocorticoid excess. Glucocorticoids and …

Lung cancer makes up one-fourth of all cancer-related mortality with the highest mortality
rate among all cancers. Despite recent scientific advancements in cancer therapeutics, the 5 …

Background: Cuproptosis is a recently identified form of programmed cell death and could
be a new direction for tumour therapy, and it has important clinical implications. Long non …